gestational hypothyroidism-induced changes in l-type calcium channels of rat aorta smooth muscle and their impact on the responses to vasoconstrictors

نویسندگان

katayoun sedaghat endocrine physiology research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran endocrine research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran

saleh zahediasl endocrine physiology research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran endocrine research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran

asghar ghasemi endocrine physiology research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran endocrine research center, research institute for endocrine sciences, shahid beheshti university of medical sciences, tehran, iran

چکیده

objective(s): thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. materials and methods: hypothyroidism was induced in female rats by administration of 6-n-propyl-2-thiouracil in drinking water (0.02%) till delivery. the offspring aorta smooth muscle (without endothelium) contractile response to kcl (10-100 mm), kcl in the presence of nifedipine (10-4-10-1 µm), phenylephrine (10-9-10-6 m) and finally, phenylephrine and caffeine 100 mm in ca2+-free krebs were measured.    results: kcl and phenylephrine-induced contractions were considerably lower in gestational hypothyroid (gh) than euthyroid offspring. gh responded to nifedipine with less sensitivity than control. the gh and control groups produced almost equal contraction in respond to phenylephrine and caffeine in ca2+-free krebs.  conclusion: this study suggests that in hypothyroid offspring l-type ca2+ channels are less functional, while intracellular ca2+ handling systems are less modified by low levels of maternal thyroid hormones.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Gestational hypothyroidism-induced changes in L-type calcium channels of rat aorta smooth muscle and their impact on the responses to vasoconstrictors

Objective(s): Thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  Considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. Materials and Methods: Hypothyroidism was induced in female rats by administ...

متن کامل

Gestational hypothyroidism-induced changes in L-type calcium channels of rat aorta smooth muscle and their impact on the responses to vasoconstrictors

OBJECTIVES Thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring. Considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. MATERIALS AND METHODS Hypothyroidism was induced in female rats by administrat...

متن کامل

the impact of attending efl classes on the level of depression of iranian female learners and their attributional complexity

می توان گفت واقعیت چند لایه ا ی کلاس های زبان انگلیسی بسیار حائز اهمیت است، زیرا عواطف و بینش های زبان آموزان تحت تاثیر قرار می گیرد. در پژوهش پیش رو، گفته می شود که دبیران با در پیش گرفتن رویکرد فرا-انسانگرایی ، قادرند در زندگی دانش آموزانشان نقش مهمی را ایفا سازند. بر اساس گفته ی ویلیامز و بردن (2000)، برای کرل راجرز، یکی از بنیان گذاران رویکرد انسانگرایی ، یادگیری بر مبنای تجربه، نوعی از یاد...

the impact of e-readiness on ec success in public sector in iran the impact of e-readiness on ec success in public sector in iran

acknowledge the importance of e-commerce to their countries and to survival of their businesses and in creating and encouraging an atmosphere for the wide adoption and success of e-commerce in the long term. the investment for implementing e-commerce in the public sector is one of the areas which is focused in government‘s action plan for cross-disciplinary it development and e-readiness in go...

the effect of oxytetracycline on serum calcium, phosphorus and magnesium in cattle

نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۸، شماره ۲، صفحات ۱۷۲-۱۷۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023